Modulation of Oxidative Stress Induced Cerebral Ischemia in Wistar Rats by Hydroalcoholic Extract of Talinum triangulare

Abstract: Background: Neuroprotection is one of considerable interest in search novel therapies to improve ischemic brain damage the present scenario. The objective investigation study actions Talinum triangulare cerebral ischemia/reperfusion induced oxidative stress Wistar rats and in-vitro antioxidant actions. Methods: Four different groups adult are selected for where group III IV treated 15 days with TTE (200mg/kg, 400mg/kg) earlier ischemia, on 16th day dissected through global ischemia by occlusion unilateral common carotid artery, prior dissection animals sedated thiopentone after induction that 30 min reperfusion was followed. Following injury various parameters such as infarct size, SOD, MDA, CAT GSH levels were assessed 48hr reperfusion. Results: Phytochemical screening indicated presence alkaloids, flavonoids, glycosides, carbohydrates, saponins, tannins resins. also showed a significant activity. Pre-treatment ischemic-reperfusion, results reported huge reduction MDA increase compared control which statistically significant. Conclusion: hydroalcoholic extract leaves in-vivo dose dependant cerebroprotective effect 200 mg/kg 400 mg/kg. Key words: triangulare, Cerebral reperfusion, Oxidative stress, Cerebroprotection, Antioxidant acivity.